Thakur M K, Oka T, Natori Y
Biochemistry and Molecular Biology Laboratory, Banaras Hindu University, Varanasi, India.
Mech Ageing Dev. 1993 Jan;66(3):283-98. doi: 10.1016/0047-6374(93)90015-j.
Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genetic instability and have attempted further to highlight the gaps that need to be bridged in order to have a clear picture of the aging phenomenon. Extensive investigations employing new and novel approaches are needed in future to elucidate the intricately interwoven patterns of molecular control that underlie the various aspects of gene expression during aging.
