Antifungal activity of Myxococcus species 1 production, physicochemical and biological properties of antibiotics from Myxococcus fulvus S110 (Myxobacterales).

Chloroform extracts of the culture supernatant of a strain of Myxococcus fulvus isolated from soil were fungistatic and prevented germination of spores of Botrytis cinerea. The antibiotics were produced during the exponential phase of growth and the effects of altering medium composition are described. The activity was fractionated into neutral, acidic and basic fractions. The neutral fraction had a molecular weight of 244 and was tentatively identified as 11-phenyl-undecadiene-2-ol. The acidic fraction was primarily n-hexadecanoic acid. The basic fraction contained components [N-(2-phenylethyl)-acetamide, and compounds tentatively identified as 1-isoquinoline carbonitrile and substituted quinolines] which have not previously been described in the myxobacteria.