Friedberg E B, Ross D T
Head Injury Center, University of Pennsylvania, Philadelphia 19104.
Neurosci Lett. 1993 Mar 5;151(1):115-9. doi: 10.1016/0304-3940(93)90060-x.
Domoic acid (DA), an analog of kainic acid, produces attentional deficits in humans who have ingested shell fish contaminated with this excitotoxin. The thalamic reticular nucleus (RT), by virtue of its location, connections and intrinsic properties, has been implicated in attentional processes. This study demonstrated the vulnerability of RT neurons following intrathalamic DA injections in rats. Lesions were characterized by almost total neuronal loss throughout the RT and sparing of adjacent populations of relay neurons in the VL and VPL. Los of RT neurons may underlie some types of attentional deficits observed in humans following DA poisoning.
软骨藻酸（DA）是一种 kainic 酸类似物，会使摄入受这种兴奋性毒素污染的贝类的人出现注意力缺陷。丘脑网状核（RT）凭借其位置、连接和内在特性，被认为与注意力过程有关。本研究证明了大鼠丘脑内注射 DA 后 RT 神经元的易损性。损伤的特征是整个 RT 几乎完全神经元丧失，而 VL 和 VPL 中相邻的中继神经元群体则未受影响。RT 神经元的丧失可能是 DA 中毒后人类出现某些类型注意力缺陷的基础。
