妊娠期糖尿病合并黑棘皮病和高雄激素血症
Acanthosis nigricans and hyperandrogenism in a pregnancy complicated by diabetes.
作者信息
Gemer O, Segal S, Segal O, Zohav E, Sassoon E
机构信息
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
出版信息
Obstet Gynecol. 1993 May;81(5 ( Pt 2)):810-1.
BACKGROUND
Acanthosis nigricans and hyperandrogenism have been associated with diabetes mellitus accompanied by insulin resistance. However, these manifestations have rarely been reported to occur as a result of the insulin resistance of pregnancy.
CASE
A 31-year-old woman with diabetes mellitus exhibited severe insulin resistance during pregnancy. At 32 weeks, daily administration of 500 U insulin was required to maintain glycemic control. Skin lesions typical of acanthosis nigricans appeared, and free testosterone levels were elevated (10.3 pg/mL). These manifestations resolved after delivery.
CONCLUSION
This case may demonstrate a correlation between reversible gestational insulin resistance and acanthosis nigricans.
背景
黑棘皮症和高雄激素血症与伴有胰岛素抵抗的糖尿病有关。然而，这些表现很少被报道是由妊娠胰岛素抵抗引起的。
病例
一名31岁的糖尿病女性在怀孕期间表现出严重的胰岛素抵抗。在孕32周时，每天需要注射500单位胰岛素来维持血糖控制。出现了典型的黑棘皮症皮肤病变，游离睾酮水平升高（10.3 pg/mL）。这些表现在分娩后消失。
结论
该病例可能表明可逆性妊娠胰岛素抵抗与黑棘皮症之间存在关联。
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