Nicolas M H, Crave J C, Fimbel S, Siméan A, Pugeat M
Laboratoire de la Clinique endocrinologique, Hôpital de l'Antiquaille, Lyon.
Presse Med. 1993;22(1):19-22.
To investigate the relationship between overweight and hyperandrogenism, a 1500 kcal/day diet was prescribed for 4 months to 23 hirsute and obese patients. This diet decreased body mass index from 29.9 +/- 4.9 to 27.2 +/- 4.4 kg/m2 (P < 0.008), but had no significant effect on fasting insulin levels (18.9 +/- 14.2 vs. 21.1 +/- 9.6 mlU/l). Weight lost increased significantly (P < 0.008) the plasma concentration of sex-hormone binding-globulin (SHBG) from 21.2 +/- 10.6 to 26.2 +/- 13.5 nmol/l and decreased significantly (P < 0.04) the SHBG-unbound testosterone concentration from 9.3 +/- 6.2 to 7.2 +/- 4.8 ng/dl, without changing the concentrations of the main androgens measured in this study. Moreover, during diet 5 patients in amenorrhea and 8 among 13 patients with irregular menstrual cycle recovered regular menses. We concluded that the control of excess body weight in hirsute women is effective but not sufficient to improve hyperandrogenism.
为研究超重与高雄激素血症之间的关系，对23名多毛且肥胖的患者采用每日1500千卡的饮食方案，为期4个月。该饮食方案使体重指数从29.9±4.9降至27.2±4.4kg/m²（P<0.008），但对空腹胰岛素水平无显著影响（18.9±14.2对21.1±9.6mlU/l）。体重减轻使性激素结合球蛋白（SHBG）的血浆浓度显著升高（P<0.008），从21.2±10.6升至26.2±13.5nmol/l，使未结合SHBG的睾酮浓度显著降低（P<0.04），从9.3±6.2降至7.2±4.8ng/dl，而本研究中所测主要雄激素的浓度未发生变化。此外，在节食期间，5名闭经患者和13名月经周期不规律患者中的8名恢复了规律月经。我们得出结论，控制多毛女性的超重状况是有效的，但不足以改善高雄激素血症。
