Lueddeckens G, Bigl H, Sperling J, Becker K, Braquet P, Förster W
Martin Luther University Halle-Wittenberg, School of Medicine, Department of Pharmacology and Toxicology, Germany.
Prostaglandins Leukot Essent Fatty Acids. 1993 Mar;48(3):261-3. doi: 10.1016/0952-3278(93)90095-e.
The i.v. bolus application of 1 nmol/kg endothelin-1 (ET-1) in anaesthetized and ventilated guinea-pigs caused an increase in mean arterial blood pressure (BP) and a bronchoconstriction. Both have been reduced or abolished by COX inhibition (ASA) or substances specifically reducing the thromboxane A2 (TXA2) generation (HOE 944) or receptor binding (BM 13177). The significant increase in TXB2 concentrations in plasma and bronchoalveolar lavage (BAL) after ET-1 challenge (15-fold and 4-fold, respectively) have been reduced or abolished by ASA as well as HOE 944 and not altered by BM 13177.
在麻醉并通气的豚鼠中静脉推注1 nmol/kg内皮素-1（ET-1）可导致平均动脉血压（BP）升高和支气管收缩。二者均可通过抑制环氧化酶（ASA）或特异性减少血栓素A2（TXA2）生成（HOE 944）或受体结合（BM 13177）的物质而减轻或消除。ET-1激发后血浆和支气管肺泡灌洗（BAL）中TXB2浓度显著升高（分别为15倍和4倍），这可被ASA以及HOE 944降低或消除，而BM 13177对其无影响。
