Ueda S, Aso S, Watanabe Y, Mizukoshi K
Department of Otolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Acta Otolaryngol Suppl. 1993;504:89-93. doi: 10.3109/00016489309128129.
Auditory evoked responses in 21 cases with tinnitus were recorded before and after the administration of intravenous lidocaine. A dosage of 1 mg/kg body weight was diluted with 20% glucose (20 ml) and administered intravenously over a one-min period. The loudness of tinnitus was evaluated during electrocochleography (ECochG) or auditory brain-stem response (ABR) recordings using a score between 0 and 11. The stimulus sound was a tone burst in a frequency that corresponded to the pitch of tinnitus. AP latency on ECochG and the inter peak latency (IPL) of wave I-III and wave III-V on ABR were prolonged momentarily and tinnitus was reduced. These findings reveal that the sites of action for lidocaine are both the inner ear and the brain-stem.
对21例耳鸣患者在静脉注射利多卡因前后记录听觉诱发电位。将1mg/kg体重的剂量用20%葡萄糖（20ml）稀释，在1分钟内静脉注射。在耳蜗电图（ECochG）或听觉脑干反应（ABR）记录期间，使用0至11的评分评估耳鸣的响度。刺激声为与耳鸣音调对应的短纯音。ECochG上的AP潜伏期以及ABR上I-III波和III-V波的峰间期（IPL）瞬间延长，耳鸣减轻。这些发现表明利多卡因的作用部位在内耳和脑干。
