Bucci F A, Lopatynsky M O, Jenkins P L, Mackay A T, Rickert D G, Gold R M
Department of Ophthalmology, Albany Medical College, New York.
Am J Ophthalmol. 1993 Apr 15;115(4):454-9. doi: 10.1016/s0002-9394(14)74446-0.
Anecdotal reports have suggested that the use of disposable contact lenses is an effective treatment for giant papillary conjunctivitis. In a prospective randomized double-masked study, we compared the clinical performance of the Acuvue (Vistakon, Jacksonville, Florida) disposable contact lens to the traditional daily-wear lens of choice, CSI (Pilkington Barnes Hind, Sunnyvale, California), in 37 patients with previously diagnosed giant papillary conjunctivitis who were examined at one-month intervals for six months. A survey questionnaire for grading symptoms disclosed significant improvement in itching, discharge, and blurred vision in both groups early in the study. Evaluation of patient preference showed that the CSI lens was strongly preferred with regard to lens handling (76% vs 8%). In contrast, the Acuvue lens was strongly preferred with regard to lens comfort (62% vs 11%). For the variable of overall lens preference, there was no significant difference between the two lenses (CSI, 43% and Acuvue, 41%). Multiple regression analysis disclosed that both lens comfort (P < .002) and lens handling (P = .05) contributed significantly to the choices made regarding the dependent variable of overall lens preference. Lens comfort (beta = .71) was observed to be approximately 50% more powerful than lens handling (beta = .48). There was no significant difference in the rate or cost of torn lenses between groups, suggesting that the Acuvue lens can withstand the physical manipulation associated with daily-wear use for up to one month. The results of this study suggest that the use of disposable contact lenses for the treatment of giant papillary conjunctivitis is at least as effective as the traditional daily-wear lens of choice.
轶事报道表明，使用一次性隐形眼镜是治疗巨乳头性结膜炎的一种有效方法。在一项前瞻性随机双盲研究中，我们将37例先前诊断为巨乳头性结膜炎的患者分为两组，一组使用Acuvue（Vistakon公司，佛罗里达州杰克逊维尔）一次性隐形眼镜，另一组使用传统的日戴型隐形眼镜CSI（Pilkington Barnes Hind公司，加利福尼亚州桑尼维尔），对他们进行为期6个月的检查，检查间隔为1个月。一份用于对症状进行分级的调查问卷显示，在研究早期，两组患者的瘙痒、分泌物和视力模糊症状均有显著改善。对患者偏好的评估表明，在镜片操作方面，患者强烈倾向于CSI镜片（76%对8%）。相比之下，在镜片舒适度方面，患者强烈倾向于Acuvue镜片（62%对11%）。对于总体镜片偏好这一变量，两种镜片之间没有显著差异（CSI为43%，Acuvue为41%）。多元回归分析表明，镜片舒适度（P < .002）和镜片操作（P = .05）对总体镜片偏好这一因变量的选择均有显著影响。观察到镜片舒适度（β = .71）的影响力比镜片操作（β = .48）大约强50%。两组之间镜片撕裂的发生率和成本没有显著差异，这表明Acuvue镜片能够承受与长达1个月的日戴使用相关的物理操作。这项研究的结果表明，使用一次性隐形眼镜治疗巨乳头性结膜炎至少与传统的首选日戴型隐形眼镜一样有效。
