Sablé-Amplis R, Sicart R
Laboratoire des Régulations des Métabolismes et Nutrition, CNRS, Université Paul Sabatier, Toulouse, France.
Ann Nutr Metab. 1993;37(1):1-7. doi: 10.1159/000177742.
The effect of consumption of apples as a supplement to a standard diet on hepatic acylcoenzyme A: cholesterol acyltransferase (ACAT) activity was investigated in adult golden hamsters (Mesocricetus auratus). The experimental diet was given for 2 months. IN response to the high-fruit intake, the level of cholesteryl esters was reduced in the liver, and hepatic ACAT activity, determined in vitro under various conditions of incubation, was lowered by about 30%. Moreover, plasma cholesterol was redistributed among the lipoproteins, with a decrease in the cholesterol transported in the ApoB-rich lipoproteins.
