Kano E, Yamazaki Y, Hayashi S, Zhang S W, Kawahara K, Ohtsubo T
Dept. of Experimental Radiology and Health Physics, Fukui Medical University.
Gan To Kagaku Ryoho. 1993 Apr;20(5):583-90.
Interactive effects of combined treatment with hyperthermia and chemotherapeutic agents or chemical substances were interpreted in the experimental aspects of medical sciences. It was also interpreted how a physiological circumferential conditions in vivo influenced on thermosensitivities of cells, tissues or individuals. Among the physiological conditions, hypoxia and insufficient nutrition apparently enhance thermosensitivity while reduce radiosensitivity. Interactive effects in combined treatments with hyperthermia and alkylating agents varies among the alkylating agent adopted. DNA strand scission by alkylating agent is increased and repair of the DNA damage is suppressed in combination with hyperthermia. Almost all the antimetabolites and botanic alkaloids are reported to show no appreciable interactive effect in combination with hyperthermia. However, a sort of derivatives of mitotic toxins interacts with hyperthermia (unpublished data). Effects of anticancer antibiotics vary due to the variety of the mechanism of action of the antibiotics. Therefore, interactive effects of these antibiotics with hyperthermia also vary among the antibiotics. Most marked interaction with hyperthermia was shown in Mitomycin C, while the cell killing effect of Actinomycin D itself was reduced reportedly by the combined hyperthermia. Further development in thermophysiology may perform an extent of elevation in human whole body temperature. It has been considered internal heating may be more efficient than external heating for the hyperthermia alone. In the other hand, local heating can chemosensitize within the localized heated area where the blood concentration of anticancer drug is even, although variety of intervention could be devised to localize anticancer drug distribution. Variety of heating modalities and the apparatus would be developed which contribute for further interdisciplinary oncotherapy in near future.
在医学科学的实验方面，对热疗与化疗药物或化学物质联合治疗的交互作用进行了解释。还解释了体内的生理周向条件如何影响细胞、组织或个体的热敏感性。在这些生理条件中，缺氧和营养不足明显增强热敏感性，同时降低放射敏感性。热疗与烷化剂联合治疗的交互作用因所采用的烷化剂而异。与热疗联合使用时，烷化剂导致的DNA链断裂增加，DNA损伤的修复受到抑制。几乎所有抗代谢物和植物生物碱据报道与热疗联合使用时均未显示出明显的交互作用。然而，一种有丝分裂毒素的衍生物与热疗相互作用（未发表数据）。抗癌抗生素的作用因抗生素作用机制的不同而有所差异。因此，这些抗生素与热疗的交互作用在不同抗生素之间也有所不同。丝裂霉素C与热疗的相互作用最为显著，而据报道联合热疗会降低放线菌素D本身的细胞杀伤作用。热生理学的进一步发展可能会使人体体温有一定程度的升高。人们认为，仅就热疗而言，内部加热可能比外部加热更有效。另一方面，局部加热可在局部加热区域内使化疗增敏，在该区域抗癌药物的血药浓度均匀，尽管可以设计多种干预措施来使抗癌药物分布局部化。在不久的将来，将会开发出各种加热方式和设备，这将有助于进一步的跨学科肿瘤治疗。
