Sasagawa I, Nakada T, Hashimoto T, Ishigooka M, Izumiya K, Kubota Y, Tomaru M
Department of Urology, Yamagata University, School of Medicine, Japan.
Arch Androl. 1993 Mar-Apr;30(2):93-8. doi: 10.3109/01485019308987740.
Hormonal profiles and testicular histology were studied in two patients with Down's syndrome with unilateral testicular tumor. Plasma levels of LH and FSH were elevated above normal ranges in both cases. In case 1, plasma testosterone level was abnormally low, but prolactin level in plasma was within the normal range. Case 2 showed elevated concentration of plasma prolactin and normal level of plasma testosterone. The administration of LH-RH resulted in low response of plasma gonadotropins. The response of plasma testosterone to the administration of HCG was abnormally suppressed in both cases. Testicular histology showed reduction of Johnsen score count and tubular diameter, and an increase in wall thickness. These results indicated that male patients with Down's syndrome have an abnormality in hypothalamo-pituitary-gonadal axis.
对两名患有唐氏综合征且单侧睾丸肿瘤的患者进行了激素水平分析和睾丸组织学研究。两名患者血浆中促黄体生成素（LH）和促卵泡生成素（FSH）水平均高于正常范围。病例1中，血浆睾酮水平异常低，但血浆催乳素水平在正常范围内。病例2显示血浆催乳素浓度升高，血浆睾酮水平正常。注射促性腺激素释放激素（LH-RH）后，血浆促性腺激素反应较低。在这两个病例中，注射人绒毛膜促性腺激素（HCG）后血浆睾酮的反应均受到异常抑制。睾丸组织学显示约翰森评分计数和小管直径减小，管壁厚度增加。这些结果表明，患有唐氏综合征的男性患者下丘脑-垂体-性腺轴存在异常。
