Wang R F, Lee P Y, Taniguchi T, Becker B, Podos S M, Serle J B, Mittag T W
Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029.
Arch Ophthalmol. 1993 Apr;111(4):535-8. doi: 10.1001/archopht.1993.01090040127046.
To evaluate the ocular effects of oxymetazoline hydrochloride, an alpha 2 agonist, in cynomolgus monkeys and albino rabbits.
Intraocular pressure was measured before and for 6 hours after application to glaucomatous monkey eyes. Outflow facility and aqueous flow rates were measured in normal monkey eyes. Uveoscleral outflow was measured in rabbit eyes. Ocular peak pulse volume was determined with the ocular blood flow system in normal and glaucomatous monkey eyes.
Single applications of ozymetazoline reduced (P < .001) intraocular pressure up to 6.0 +/- 1.0 mm Hg (mean +/- SEM). Enhancement of the ocular hypotensive effect was observed with 5-day twice-daily administration. Outflow facility was unaltered; aqueous flow rate was decreased (P < .001) by 39% in the treated eyes compared with baseline values; and uveoscleral outflow was increased (P < .005) by 56% in the treated eye. Peak pulse volume was unchanged.
Oxymetazoline reduces intraocular pressure by decreasing aqueous humor flow rates and increasing uveoscleral outflow. Oxymetazoline may have clinical potential as an ocular hypotensive drug.
评估α2激动剂盐酸奥洛他定对食蟹猴和白化兔的眼部影响。
对青光眼猴眼用药前及用药后6小时测量眼压。在正常猴眼中测量房水流畅系数和房水流量。在兔眼中测量葡萄膜巩膜外流。用眼部血流系统测定正常和青光眼猴眼的眼部峰值脉冲容积。
单次应用奥洛他定可使眼压降低（P <.001），降幅高达6.0±1.0毫米汞柱（平均值±标准误）。每日两次给药5天可增强降眼压效果。房水流畅系数未改变；与基线值相比，治疗眼的房水流量降低（P <.001）39%；治疗眼的葡萄膜巩膜外流增加（P <.005）56%。峰值脉冲容积未改变。
奥洛他定通过降低房水流量和增加葡萄膜巩膜外流来降低眼压。奥洛他定作为一种降眼压药物可能具有临床潜力。
