Galderisi M, Celentano A, Tammaro P, Mureddu G F, Garofalo M, de Simone G, de Divitiis O
Division of Cardioangiology, Second Medical School, Federico II University of Naples, Italy.
Am J Hypertens. 1993 Feb;6(2):114-20. doi: 10.1093/ajh/6.2.114.
The relation between 24-h ambulatory blood pressure monitoring and echocardiographic left ventricular (LV) anatomy and function was examined in 30 young, normotensive offspring (16 men, 14 women) of hypertensive, parents and in 20 offspring (12 men, 8 women) of normotensive parents, comparable for age, clinical blood pressure, and gender. Offspring of hypertensive subjects exhibited higher body mass index (P < .01), relative wall thickness, and LV mass/height (both P < .001). No significant difference was found in LV chamber dimensions and in either systolic or diastolic function. The 24-h systolic and diastolic blood pressures were higher in offspring of hypertensive subjects than in controls (P < .001 and P < .0001, respectively), as was the coefficient of variation of 24 h systolic blood pressure (P < .01). In pooled groups, LV mass was positively related to daytime systolic blood pressure (r = 0.48), daytime diastolic blood pressure (r = 0.47) (both P < .001), and the coefficient of variation of 24 h diastolic blood pressure (r = 0.37, P < .01). In a multiple regression model, including as variables, body mass index, daytime systolic and diastolic blood pressures, male gender, and family history of hypertension were the major independent predictors of LV mass (both P < .0001), with an additional contribution of the coefficient of variation of 24 h diastolic blood pressure (P < .05). We conclude that male gender and a family history of hypertension are stronger determinants of early changes in cardiac structure than hemodynamic load in a group of young, normotensive adults.
对30名患有高血压的父母的年轻、血压正常的后代（16名男性，14名女性）以及20名血压正常的父母的后代（12名男性，8名女性）进行了研究，比较他们在年龄、临床血压和性别方面的情况，以探讨24小时动态血压监测与超声心动图左心室（LV）解剖结构和功能之间的关系。高血压受试者的后代表现出更高的体重指数（P <.01）、相对壁厚和左心室质量/身高（两者P <.001）。左心室腔尺寸以及收缩或舒张功能均未发现显著差异。高血压受试者的后代24小时收缩压和舒张压均高于对照组（分别为P <.001和P <.0001），24小时收缩压的变异系数也是如此（P <.01）。在合并组中，左心室质量与白天收缩压（r = 0.48）、白天舒张压（r = 0.47）（两者P <.001）以及24小时舒张压的变异系数（r = 0.37，P <.01）呈正相关。在一个多元回归模型中，将体重指数、白天收缩压和舒张压、男性性别以及高血压家族史作为变量，它们是左心室质量的主要独立预测因素（两者P <.0001），24小时舒张压变异系数也有额外贡献（P <.05）。我们得出结论，在一组年轻、血压正常的成年人中，男性性别和高血压家族史比血流动力学负荷更能决定心脏结构的早期变化。
