Harris M
Joint Department of Maxillofacial Surgery and Oral Medicine, Eastman Dental Hospital, London.
Br J Oral Maxillofac Surg. 1993 Apr;31(2):89-94. doi: 10.1016/0266-4356(93)90168-v.
Aggressive central giant cell granulomas may be eliminated by administering human calcitonin 0.5 mg (100 iu) deep subcutaneously for 1 year. This avoids the need for mutilating surgery or radiotherapy in growing children. Aggressive recurrent peripheral lesions (the giant cell epulis) can also be treated by excision after calcitonin therapy. These giant cell granulomas should be redefined as osteoclast granulomas, and the aneurysmal bone cyst, the cystic osteoclast granuloma. However the stimulus for the disturbance in the osteo progenitor spindle cell needs to be defined.
侵袭性中央巨细胞肉芽肿可通过皮下深部注射0.5毫克（100国际单位）人降钙素，持续1年来消除。这避免了在正在生长的儿童中进行致残性手术或放疗的必要性。侵袭性复发性周围性病变（巨细胞龈瘤）也可在降钙素治疗后通过切除进行治疗。这些巨细胞肉芽肿应重新定义为破骨细胞肉芽肿，以及动脉瘤样骨囊肿，即囊性破骨细胞肉芽肿。然而，骨祖细胞梭形细胞紊乱的刺激因素仍需明确。
