L'vov K M, Iskakov A A
Biofizika. 1993 Jan-Feb;38(1):7-11.
Mechanism of the death of free radicals formed under the effect of different destructing factors in proteins without a prosthetic group is considered. The death of macroradicals in proteins is suggested to be due to a recombination of free radical states of aromatic amino acid residues and atom hydrogen braking away as a result of transformation of the middle radicals -NH-C alpha R-CO- from the nearest NH-group. Possible way of middle radicals transformation is proposed which leads to the breakage of hydrogen. The mechanism of macroradicals death considered explains basic experimental results obtained in this field.
研究了在无辅基蛋白质中不同破坏因素作用下形成的自由基的死亡机制。蛋白质中大分子自由基的死亡被认为是由于芳香族氨基酸残基的自由基状态与因中间自由基-NH-CαR-CO-从最近的NH基团转化而脱离的氢原子发生重组。提出了中间自由基转化导致氢断裂的可能途径。所考虑的大分子自由基死亡机制解释了该领域获得的基本实验结果。
