Piruzian L A, Mikhaĭlovskiĭ E M
Izv Akad Nauk Ser Biol. 1993 Jan-Feb(1):112-20.
Potential indications for bacterial strains-producers of biologically active substances to be utilized for microbial saprotrophic pharmacotherapy are presented. These indications include some infectious diseases and tumors, a number of noninfectious diseases, transplantation and contraception. The cardinal problem of microbial pharmacotherapy, the capacity of strains-producers of getting acclimatized to the patient organism, is discussed. For its solution, a "microbiological passportization of a patient" ("saprotrophic mapping"), that is drawing up a map of patient microbiological status, is proposed. This "saprotrophic secretory passportization (mapping)" of strains-producers is first submitted for consideration. A strategy of future microbial pharmacotherapy is stated. The necessity of careful approbation of this kind of therapy is emphasized.
介绍了具有生物活性物质的细菌菌株作为微生物腐生营养药物治疗的潜在适应症。这些适应症包括一些传染病和肿瘤、多种非传染病、移植和避孕。讨论了微生物药物治疗的主要问题，即菌株生产者适应患者机体的能力。为解决这一问题，提出了“患者微生物学护照化”（“腐生营养图谱绘制”），即绘制患者微生物学状态图。首次提交了这种菌株生产者的“腐生营养分泌护照化（图谱绘制）”以供审议。阐述了未来微生物药物治疗的策略。强调了对这种治疗进行仔细验证的必要性。
