Lipton A, Demers L, Daniloff Y, Curley E, Hamilton C, Harvey H, Witters L, Seaman J, Van der Giessen R, Seyedin S
M.S. Hershey Medical Center, Hershey, PA 17033.
Clin Chem. 1993 Apr;39(4):614-8.
Pyridinoline (PYD) and deoxypyridinoline (DPD), two collagen-based cross-links found in bone, were measured by high-performance liquid chromatography in urine samples from 65 control subjects and 97 patients with either untreated or progressive cancer. Patients with cancer had significantly (P < 0.001) higher urine concentrations of PYD and DPD than did control subjects. Both cross-links were increased in cancer patients with and without clinically detectable bone metastases, although patients with bone and liver involvement had higher mean concentrations. The mean concentrations of both cross-links were also significantly higher in the urine samples of inpatients than in an outpatient ambulatory population. These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.
吡啶啉（PYD）和脱氧吡啶啉（DPD）是在骨骼中发现的两种基于胶原蛋白的交联物，通过高效液相色谱法对65名对照受试者和97名未治疗或患有进展性癌症的患者的尿液样本进行了检测。癌症患者尿液中PYD和DPD的浓度显著高于对照受试者（P < 0.001）。无论有无临床可检测到的骨转移，癌症患者的这两种交联物均升高，不过同时有骨和肝受累的患者平均浓度更高。住院患者尿液样本中这两种交联物的平均浓度也显著高于门诊流动人群。这些发现表明，检测尿液中的PYD和DPD可能有助于评估癌症患者的骨转移和骨吸收情况。
