Rosenthal H G, Terek R M, Lane J M
Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City.
Clin Orthop Relat Res. 1993 Apr(289):66-72.
Management of extremity soft-tissue sarcomas requires accurate clinical staging, pathologic diagnosis, surgical resection with a wide margin, and adjuvant radiation therapy for high-grade lesions. Brachytherapy offers a clean benefit in local control for large (> 5 cm) high-grade sarcomas. The role of radiation therapy for small high-grade and all low-grade soft-tissue sarcomas still is being evaluated. Survival is function of histologic grade, age of patient, size and location of the tumor, metastases, and adequacy of the surgical resection. Efficacy of chemotherapy has yet to be proven.
肢体软组织肉瘤的治疗需要准确的临床分期、病理诊断、广泛切缘的手术切除以及对高级别病变进行辅助放射治疗。近距离放射治疗对大型（>5cm）高级别肉瘤的局部控制有明显益处。放射治疗在小型高级别和所有低级别软组织肉瘤中的作用仍在评估中。生存率取决于组织学分级、患者年龄、肿瘤大小和位置、转移情况以及手术切除的充分性。化疗的疗效尚未得到证实。
