Bouchama A, el-Yazigi A, Yusuf A, al-Sedairy S
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Crit Care Med. 1993 Apr;21(4):551-4. doi: 10.1097/00003246-199304000-00016.
To investigate the potential role of taurine as a hypothermic modulator during heatstroke.
Prospective analyses.
Heatstroke Center in makkah, Saudi Arabia.
Twenty-nine adult patients with heatstroke.
High-performance liquid chromatography was used to measure plasma and urine taurine concentrations in heatstroke patients on admission (precooling) and 24 hrs after complete cooling (postcooling).
There were 18 males and 11 females with a mean rectal temperature of 42.2 +/- 0.14 degrees C. At the precooling time period, the taurine concentrations were increased (plasma 180 +/- 14 mumol/L; urine 4142 +/- 720 mumol/L [normal ranges 45.5 to 138.2 and 168 to 1890 mumol/L, respectively]). At the postcooling time period, taurine concentrations were significantly (p < .0001) decreased (54 +/- 6 and 802 +/- 160 mumol/L for plasma and urine, respectively). No correlation was found between taurine and creatine kinase activity, or between precooling temperature and taurinemia or taurinuria.
The source and clinical significance of the increased taurine concentrations are to be determined. The involvement of taurine in the regulation of core body temperature suggests that it may have an adaptive role in heatstroke.
研究牛磺酸在中暑期间作为体温调节因子的潜在作用。
前瞻性分析。
沙特阿拉伯麦加的中暑中心。
29例成年中暑患者。
采用高效液相色谱法测量中暑患者入院时（预降温）和完全降温后24小时（降温后）血浆和尿液中的牛磺酸浓度。
18例男性和11例女性，平均直肠温度为42.2±0.14℃。在预降温阶段，牛磺酸浓度升高（血浆180±14μmol/L；尿液4142±720μmol/L[正常范围分别为45.5至138.2和168至1890μmol/L]）。在降温后阶段，牛磺酸浓度显著降低（血浆和尿液分别为54±6和802±160μmol/L，p<0.0001）。未发现牛磺酸与肌酸激酶活性之间、预降温温度与血牛磺酸或尿牛磺酸之间存在相关性。
牛磺酸浓度升高的来源及临床意义有待确定。牛磺酸参与核心体温调节提示其在中暑中可能具有适应性作用。
