Motz W, Vogt M, Scheler S, Schwartzkopff B, Strauer B E
Abteilung für Kardiologie, Pneumologie und Angiologie, Universität Düsseldorf.
Dtsch Med Wochenschr. 1993 Apr 16;118(15):535-40. doi: 10.1055/s-2008-1059360.
The coronary microcirculation was investigated by the argon gas method in ten patients (eight men, two women; mean age 56 [44-63] years) before and after an average of 12.9 (9-18) months of treatment with the cardioselective beta-receptor blocker bisoprolol. Left ventricular muscle mass was measured echocardiographically, before and after the treatment. All these patients were known to have hypertension, with exercise-related angina and ischaemic signs in the resting ECG, but normal coronary angiograms. After the treatment period both maximal coronary perfusion and coronary reserve had increased by 22%. At the same time, left ventricular muscle mass had decreased from 161 +/- 18 to 146 +/- 21 g/m2. These results demonstrate that blood pressure reducing treatment can bring about not only a regression of left ventricular hypertrophy, but also an improvement in coronary reserve.
采用氩气法对10例患者（8例男性，2例女性；平均年龄56[44 - 63]岁）进行冠状动脉微循环研究，这些患者在接受心脏选择性β受体阻滞剂比索洛尔平均12.9（9 - 18）个月治疗前后进行了研究。在治疗前后通过超声心动图测量左心室肌肉质量。所有这些患者均患有高血压，有运动相关心绞痛且静息心电图有缺血迹象，但冠状动脉造影正常。治疗期后，最大冠状动脉灌注和冠状动脉储备均增加了22%。同时，左心室肌肉质量从161±18降至146±21 g/m²。这些结果表明，降压治疗不仅可以使左心室肥厚消退，还可以改善冠状动脉储备。
