Shucard D W, Andrew M
Res Commun Chem Pathol Pharmacol. 1977 Mar;16(3):401-10.
The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose-response data are presented for the range of 5 mg/kg to 50 mg/kg. A long-lasting dose-dependent bradycardia was produced. This finding is in contrast to the clasically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia-producing effects of atropine.
使用多种剂量的硫酸阿托品，通过慢性颈静脉插管注入未麻醉的豚鼠体内，研究其对心率的影响；给出了5毫克/千克至50毫克/千克剂量范围内的剂量反应数据。产生了持久的剂量依赖性心动过缓。这一发现与经典报道的阿托品对人和狗的作用相反：心动过速有时先出现短暂的心动过缓。因此，豚鼠可能是研究阿托品拟副交感神经、产生心动过缓作用的极佳模型。
