Bretherton-Watt D, Ghatei M A, Bloom S E, Williams S, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom.
J Clin Endocrinol Metab. 1993 Apr;76(4):1072-4. doi: 10.1210/jcem.76.4.8473384.
We have detected islet amyloid polypeptide (IAPP)-like immunoreactivity (-LI) in human pancreas and in a range of endocrine tumors, including oat cell carcinoma of the lung and pancreatic tumours producing insulin, gastrin, glucagon, and vasoactive intestinal peptide. Gel permeation chromatography of the IAPP-LI revealed that, except in the carcinoid, more than 80% coeluted with synthetic human IAPP. The remaining immunoreactivity consisted of variable amounts of larger and smaller molecular forms. The concentration of IAPP-LI in the circulation of patients with diagnosed pancreatic endocrine tumors was not significantly elevated above normal fasting levels. IAPP is, therefore, produced by a range of endocrine tumors and may relate to the deposition of endocrine amyloid.
我们已在人类胰腺以及一系列内分泌肿瘤中检测到胰岛淀粉样多肽（IAPP）样免疫反应性（-LI），这些内分泌肿瘤包括肺燕麦细胞癌以及产生胰岛素、胃泌素、胰高血糖素和血管活性肠肽的胰腺肿瘤。对IAPP-LI进行凝胶渗透色谱分析显示，除类癌外，超过80%的IAPP-LI与合成人IAPP共洗脱。其余免疫反应性由数量不等的较大和较小分子形式组成。已确诊胰腺内分泌肿瘤患者循环中的IAPP-LI浓度并未显著高于正常空腹水平。因此，IAPP由一系列内分泌肿瘤产生，可能与内分泌淀粉样物质的沉积有关。
