Johnson M R, Riddle A F, Grudzinskas J G, Sharma V, Campbell S, Collins W P, Lightman S L, Mason B, Nicolaides K H
Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
Hum Reprod. 1993 Feb;8(2):316-22. doi: 10.1093/oxfordjournals.humrep.a138043.
The endocrine function of the corpus luteum and placenta and the inter-relationships between ovarian steroids and the placental proteins in pregnancies achieved following ovarian stimulation, in-vitro fertilization and embryo transfer (IVF-ET) have been investigated. The serum concentrations of human chorionic gonadotrophin (HCG), Schwangerschaft protein-1 (SP-1), pregnancy-associated plasma protein A (PAPP-A), progesterone and oestradiol were measured at weekly intervals between the 4th (ET plus 2 weeks) and 14th week of gestation in 86 pregnancies. The mean concentrations of the placental proteins and oestradiol were significantly higher in twin than in singleton pregnancies from as early as 5 weeks gestation, but the mean concentrations of progesterone were significantly higher only at the end of the first trimester. Ranking, as demonstrated by the presence of statistically significant correlations between serum levels of each substance analysed in week 13 with those of preceding weeks, was established for progesterone and SP-1 from the 5th week, for oestradiol and PAPP-A from the 7th week and for HCG from the 8th week of gestation. The presence of statistically significant correlations between each substance analysed suggests that the placenta becomes the dominant source of oestradiol from 8 weeks gestation and of progesterone not until 12 weeks gestation, and that the placental synthesis of HCG, SP-1, PAPP-A, oestradiol and progesterone appear to be linked. There were no statistically significant correlations between the serum concentrations of HCG and either progesterone or oestradiol until the production of each had become predominantly placental.
研究了在卵巢刺激、体外受精和胚胎移植（IVF-ET）后妊娠中黄体和胎盘的内分泌功能，以及卵巢类固醇与胎盘蛋白之间的相互关系。在86例妊娠中，于妊娠第4周（胚胎移植加2周）至第14周期间每周测量血清人绒毛膜促性腺激素（HCG）、妊娠相关蛋白-1（SP-1）、妊娠相关血浆蛋白A（PAPP-A）、孕酮和雌二醇的浓度。从妊娠5周起，双胎妊娠中胎盘蛋白和雌二醇的平均浓度显著高于单胎妊娠，但仅在孕早期末孕酮的平均浓度显著更高。通过第13周分析的每种物质的血清水平与前几周血清水平之间存在统计学显著相关性来证明的排序，从妊娠第5周起确定了孕酮和SP-1的排序，从第7周起确定了雌二醇和PAPP-A的排序，从第8周起确定了HCG的排序。所分析的每种物质之间存在统计学显著相关性表明，从妊娠8周起胎盘成为雌二醇的主要来源，而直到妊娠12周才成为孕酮的主要来源，并且HCG、SP-1、PAPP-A、雌二醇和孕酮的胎盘合成似乎是相关联的。在每种物质的产生主要由胎盘主导之前，HCG的血清浓度与孕酮或雌二醇之间均无统计学显著相关性。
