Golan A, Bukovsky I, Pansky M, Schneider D, Weinraub Z, Caspi E
Department of Obstetrics and Gynaecology, Assaf Harofeh Medical Centre, Zerifin, Israel.
Hum Reprod. 1993 Mar;8(3):450-2. doi: 10.1093/oxfordjournals.humrep.a138070.
To determine whether pre-operative treatment with gonadotrophin-releasing hormone (GnRH) analogue may have a beneficial effect on surgery outcome, 53 patients with symptomatic fibroid uteri awaiting myomectomy or transabdominal hysterectomy (TAH), were randomly divided into a study group (n = 29) and a control group (n = 24). The study group of patients were treated by an i.m. injection of D-Trp6 LHRH microcapsules at 2 months and 1 month prior to surgery. The control group had no pre-operative treatment. Haemoglobin concentration and oestradiol, follicle-stimulating hormone and luteinizing hormone concentrations were measured at 2 months and 1 month prior to surgery, and at surgery. The duration of surgery was shorter in the study group (49 versus 70 min in the hysterectomy group) and intra-operative blood loss was less (208 versus 309 ml in the hysterectomies and 320 versus 476 ml in the myomectomies). Pre-operative treatment with GnRH-agonists which induces shrinkage of the uterus and fibroids is therefore efficient in shortening the duration of surgery, and diminishing the intra-operative blood loss in surgery for fibroid uteri. Such pre-operative treatment is therefore a useful addition to surgery in cases with symptomatic fibroid uteri.
为了确定术前使用促性腺激素释放激素（GnRH）类似物是否可能对手术结果产生有益影响，将53例等待子宫肌瘤切除术或经腹子宫切除术（TAH）的有症状子宫肌瘤患者随机分为研究组（n = 29）和对照组（n = 24）。研究组患者在手术前2个月和1个月通过肌肉注射D-色氨酸6促黄体生成素释放激素微胶囊进行治疗。对照组未进行术前治疗。在手术前2个月和1个月以及手术时测量血红蛋白浓度、雌二醇、促卵泡激素和促黄体生成素浓度。研究组的手术时间较短（子宫切除组为49分钟，而对照组为70分钟），术中失血量较少（子宫切除术分别为208毫升和309毫升，子宫肌瘤切除术分别为320毫升和476毫升）。因此，术前使用GnRH激动剂诱导子宫和肌瘤缩小，可有效缩短手术时间，并减少子宫肌瘤手术中的术中失血量。因此，这种术前治疗对于有症状子宫肌瘤患者的手术是一种有用的辅助手段。
