Fournié A, Valverde C, Tap G, Bazerque J J, Ayrolles C
Rev Rhum Mal Osteoartic. 1977 Feb;44(2):91-8.
The production of acute hypocalcemia was investigated using either 80 U. MRC of salmon calcitonin or 160 1. mrc of pork calcitonin in 117 subjects (58 patients with Paget's disease, 22 with osteoporosis, 22 with Sudeck-Leriche algodystrophy and 15 control subjects). The results obtained with the two types of calcitonin did not differ. Induced acute hypocalcemia was more pronounced in patients with Paget's disease than in the other subjects studied. In patients with Paget's disease there were statistically significant correlations between the hypocalcemia produced and the initial levels of alkaline phosphatase and total 24 hours urinary hydroxyproline.
在117名受试者(58例佩吉特病患者、22例骨质疏松症患者、22例苏戴克-勒里什骨营养不良患者和15名对照受试者)中,使用80单位英国医学研究委员会(MRC)的鲑鱼降钙素或160国际单位MRC的猪降钙素研究急性低钙血症的产生情况。两种降钙素获得的结果没有差异。佩吉特病患者诱导的急性低钙血症比其他研究对象更明显。在佩吉特病患者中,产生的低钙血症与碱性磷酸酶初始水平和24小时尿总羟脯氨酸之间存在统计学上的显著相关性。