Little J D, Romans S E
Department of Psychological Medicine, Dunedin Hospital, New Zealand.
Int Clin Psychopharmacol. 1993 Spring;8(1):67-70. doi: 10.1097/00004850-199300810-00012.
The case of an organic psychosis following the readministration of an amphetamine-like anorexiant is described. Previous therapeutic use of the same drug 2 years earlier was without adverse effect. Similar phenomena have been reported with other drugs, and both behavioural sensitization and kindling are possible explanations. The latter, however, provides a parsimonious explanation, a therapeutic rationale, and brings together seemingly disparate laboratory and clinical phenomena.
本文描述了一例在再次服用苯丙胺类食欲抑制剂后发生的器质性精神病病例。两年前曾使用过同一种药物进行治疗，未出现不良反应。其他药物也有类似现象的报道，行为敏化和点燃效应都可能是其原因。然而，点燃效应提供了一个简洁的解释、一种治疗原理，并将看似不同的实验室和临床现象联系在一起。
