Hari P R, Sharma C P
Biosurface Technology Division, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
J Biomater Appl. 1993 Apr;7(4):375-81. doi: 10.1177/088532829300700405.
Upon exposure to blood, rapid adsorption of proteins is the initial event at the contacting surface, followed by the adhesion of platelets and other blood components. Surfaces absorbing albumin appear to possess antithrombotic character in discouraging adhesion of platelets. Therefore, for the development of a blood contacting device, the interfacial events are extremely important and need serious investigation. We have attempted to observe the variations in competitive adsorption of fibrinogen and albumin onto the polyetherurethane urea (PEUU) surface in the presence of external lubricant, such as calcium stearate and silicone fluid coating. It seems, in the presence of such mediators, that fibrinogen adsorption is increased relatively with reduction in albumin at the surface.
接触血液后，蛋白质的快速吸附是接触表面的初始事件，随后是血小板和其他血液成分的黏附。吸附白蛋白的表面似乎具有抗血栓形成特性，可抑制血小板黏附。因此，对于血液接触装置的研发，界面事件极其重要，需要认真研究。我们试图观察在硬脂酸钙和硅油涂层等外部润滑剂存在的情况下，纤维蛋白原和白蛋白在聚醚聚氨酯脲（PEUU）表面的竞争性吸附变化。在这些介质存在的情况下，表面的纤维蛋白原吸附相对增加，而白蛋白吸附减少。
