家族性类风湿关节炎的免疫遗传学：对41个多病例家族的研究。

Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families.

作者信息

Taneja V, Mehra N K, Singh R R, Anand C, Malaviya A N

机构信息

Histocompatibility and Immunogenetics Unit, All India Institute of Medical Sciences, New Delhi.

出版信息

J Rheumatol. 1993 Feb;20(2):253-8.

PMID:8474060

Abstract

HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (chi 2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

摘要

对来自印度北部的41个无亲缘关系且有多例类风湿性关节炎患者的家庭进行了HLA单倍型研究。根据孟德尔分离定律，患病同胞对共享父母HLA单倍型的频率高于预期（卡方=13.6）。采用同胞对比例法，在患病同胞中观察到父母单倍型的非随机分离。70%的先证者中观察到HLA - DR4，而在DR4阴性的先证者中，DR10出现得更频繁。然而，在这些家庭中未观察到与该疾病有特定的单倍型关联。