Ekeström S, Samnegård H
Scand J Thorac Cardiovasc Surg. 1977;11(1):51-5. doi: 10.3109/14017437709167813.
The effect of intravenous administration of 0.3 g of Xantinoli nicotans (Complamin) and 40 mg of papaverine on internal carotid artery (ICA) blood flow in 17 conscious, newly operated patients was studied with the aid of electromagnetic flowmetry. A flow probe was attached to the ICA after carotid reconstruction. Administration of Complamin resulted in a significant decrease in arterial mean pressure and a corresponding decrease in ICA flow. The arterial mean pressure also diminished after administration of papaverine, but the decrease was moderate and did not influence ICA flow. The results indicate that the cerebral vascular autoregulation may be impaired in the early postoperative period. Vasoactive substances, which cause decreased arterial pressure, also influence ICA flow and should be avoided in patients newly operated upon for occlusive disease of the carotid artery.
借助电磁血流测量法，研究了静脉注射0.3 g烟酰黄嘌呤（Complamin）和40 mg罂粟碱对17例清醒的新手术患者颈内动脉（ICA）血流的影响。在颈动脉重建后，将血流探头附着于颈内动脉。注射Complamin导致动脉平均压显著降低，颈内动脉血流相应减少。注射罂粟碱后动脉平均压也降低，但降幅适中，且未影响颈内动脉血流。结果表明，术后早期脑血管自动调节功能可能受损。导致动脉压降低的血管活性物质也会影响颈内动脉血流，对于因颈动脉闭塞性疾病而接受新手术的患者应避免使用。
