Zotz R B, Fritschka E, Lange R, Erhard J, Beste M, Skworc K, Breuer N
Abteilungen für Gastroenterologie, Klinikum der Universität, GHS, Essen.
Med Klin (Munich). 1993 Mar 15;88(3):139-42.
Endothelin, one of the most potent vasoconstrictors known today, is released by the vascular endothelium. Patients after liver transplantation and patients with liver cirrhosis show significantly higher plasma endothelin concentrations and significantly reduced results in the quantitative liver function tests (ICG-HL, GEC, Lidocaine-HL, MEGX) compared with healthy control persons. The plasma endothelin concentrations were better correlated with the more liver bloodflow dependent function tests (ICG-HL, Lidocaine-HL) than with the more metabolic-capacity dependent function tests (GEC, MEGX). As cyclosporine A in vitro can increase the liberation of endothelin, we conclude that in patients after liver transplantation an endothelin mediated cyclosporine induced hepatotoxicity might be the reason for the demonstrated association.
内皮素是目前已知的最有效的血管收缩剂之一，由血管内皮释放。肝移植术后患者和肝硬化患者的血浆内皮素浓度显著高于健康对照者，并且在定量肝功能试验（吲哚菁绿肝清除率、半乳糖清除率、利多卡因肝清除率、单乙基甘氨酰二甲苯胺）中的结果显著降低。与代谢能力依赖性更强的功能试验（半乳糖清除率、单乙基甘氨酰二甲苯胺）相比，血浆内皮素浓度与肝血流依赖性更强的功能试验（吲哚菁绿肝清除率、利多卡因肝清除率）的相关性更好。由于环孢素A在体外可增加内皮素的释放，我们得出结论，在肝移植术后患者中，内皮素介导的环孢素诱导的肝毒性可能是所显示关联的原因。
