Yamamoto R, Wada A, Asada Y, Niina H, Sumiyoshi A
Department of Pharmacology, Miyazaki Medical College, Japan.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Feb;347(2):238-40. doi: 10.1007/BF00169274.
In the isolated perfused rat mesenteric vasculature with intestine attached N omega-nitro-L-arginine (L-NNA) (30 mumol/l), an inhibitor of nitric oxide (NO) synthesis from L-arginine, did not alter spontaneous noradrenaline outflow. Transmural field stimulation (2-10 Hz) caused a frequency-dependent increase in noradrenaline outflow. The evoked overflow was reduced by L-NNA. L-Arginine (0.3 mmol/l) attenuated the inhibition of noradrenaline overflow by L-NNA. These results suggest that NO increases the release of noradrenaline in rat mesenteric vasculature.
在带有肠段的离体灌注大鼠肠系膜血管系统中，一氧化氮（NO）从L-精氨酸合成的抑制剂Nω-硝基-L-精氨酸（L-NNA）（30 μmol/l）不会改变去甲肾上腺素的自发性流出。跨壁场刺激（2 - 10 Hz）引起去甲肾上腺素流出量呈频率依赖性增加。L-NNA可减少诱发的溢出。L-精氨酸（0.3 mmol/l）减弱了L-NNA对去甲肾上腺素溢出的抑制作用。这些结果表明，NO可增加大鼠肠系膜血管系统中去甲肾上腺素的释放。
