Garcia E, Sotelo J
Laboratory of Neuroimmunology, National Institute of Neurology and Neurosurgery, Mexico, D.F.
Neurochem Res. 1993 May;18(5):613-6. doi: 10.1007/BF00966939.
It has been suggested that the therapeutic response to electroconvulsive therapy in depressed patients could be mediated by functional changes in the dopaminergic pathways; a favorable response to electroconvulsive therapy was also observed recently in patients with Parkinson's disease. To study a possible interference of electroconvulsive shock in the course of MPTP-induced parkinsonism in rodents, we measured the striatal content of dopamine in MPTP-treated mice that received electroconvulsive shock at various intervals in the course of MPTP neurotoxicity. Our results showed no immediate or delayed differences in striatal dopamine content of animals that received MPTP and electroconvulsive shock when compared with animals that received only MPTP, thus suggesting that the strong biological effects of MPTP and electroconvulsive shock on the brain may follow different biochemical mechanisms.
有人提出，抑郁症患者对电休克治疗的治疗反应可能由多巴胺能通路的功能变化介导；最近在帕金森病患者中也观察到对电休克治疗的良好反应。为了研究电休克对啮齿动物中MPTP诱导的帕金森病病程的可能干扰，我们测量了在MPTP神经毒性过程中于不同时间间隔接受电休克的MPTP处理小鼠纹状体中的多巴胺含量。我们的结果表明，与仅接受MPTP的动物相比，接受MPTP和电休克的动物纹状体多巴胺含量没有立即或延迟的差异，因此表明MPTP和电休克对大脑的强大生物学效应可能遵循不同的生化机制。
