Chiodo L A, Antelman S M
Science. 1980 Nov 14;210(4471):799-801. doi: 10.1126/science.6254148.
Repeated electroconvulsive shock, applied to rats, induces a subsensitivity of dopamine autoreceptors located in the substantia nigra as indexed by single-unit electrophysiological techniques. This reduced sensitivity is time-dependent, since effects similar to those seen with repeated treatment were also observed when single electroconvulsive shock was followed by an appropriate treatment-free interval. These data, coupled with identical results after the repeated administration of tricyclic antidepressants, raise the possibility that a reduction of dopamine autoreceptor sensitivity could underlie both electroconvulsive shock and pharmacological treatment of depression.
对大鼠施加重复电惊厥休克，通过单单位电生理技术检测发现，位于黑质的多巴胺自身受体出现亚敏感性。这种敏感性降低具有时间依赖性，因为在单次电惊厥休克后给予适当的无治疗间隔期时，也观察到了与重复治疗相似的效果。这些数据，再加上三环类抗抑郁药重复给药后得到的相同结果，增加了一种可能性，即多巴胺自身受体敏感性降低可能是电惊厥休克和抑郁症药物治疗的共同基础。
