[小鼠胚胎成纤维细胞自发肿瘤演化过程中不同核型特征的独立变异性]
[The independent variability of different karyotypic characteristics during the spontaneous neoplastic evolution of mouse embryo fibroblasts].
作者信息
Glazko T T
出版信息
Tsitologiia. 1993;35(1):36-45.
The dynamics of some karyotype characteristics throughout the spontaneous neoplastic evolution of embryonal fibroblasts of different mouse strains was studied using a differential staining of chromosomes. The independent variability of chromosome modal numbers, the number of polyploid cells in the cell line, the number of chromosomal rearrangements within one cell, the activity of formation of different types of chromosomal rearrangements and the activity of interactions of the homologous chromosomes in 15 studied cell lines were revealed. Possible levels of variability regulations of different karyotype characteristics are discussed.
利用染色体的差异染色，研究了不同小鼠品系胚胎成纤维细胞自发肿瘤演变过程中某些核型特征的动态变化。揭示了15个研究细胞系中染色体众数的独立变异性、细胞系中多倍体细胞的数量、单个细胞内染色体重排的数量、不同类型染色体重排形成的活性以及同源染色体相互作用的活性。讨论了不同核型特征变异调控的可能水平。
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