Knight L C, Eccles R
Common Cold and Nasal Research Centre, University of Wales College of Cardiff, United Kingdom.
Acta Otolaryngol. 1993 Mar;113(2):196-200. doi: 10.3109/00016489309135792.
Middle ear pressure and nasal airway resistance were measured over 7 1/2h in 8 subjects (age 18-32) with symptomatic acute upper respiratory tract infection. The mean middle ear pressure was -13 +/- 1.5 daPa (s.e.m.) with a range between 65 to -140 daPa. The mean total nasal resistance was 0.4 +/- 0.02 Pa/cm3/s (s.e.m.) with a range between 0.20 to 1.28 Pa/cm3/s. Unilateral nasal airway resistance exhibited reciprocal fluctuations with a range between 0.18-3.60 Pa/cm3/s. The mean difference between the highest and lowest unilateral nasal resistance values for each subject was 1.48 +/- 0.22 Pa/cm3/s (n = 16). No correlation was found between unilateral nasal airway resistance and middle ear pressure. Total nasal airway resistance had an inverse correlation with middle ear pressure r = 0.32, r2 = 0.11, n = 176 (p < 0.001). The results indicate that the generation of a negative middle ear pressure in acute upper respiratory tract infection occurred in a manner consistent with intermittent obstruction of the Eustachian tube and gradual middle ear gas absorption. Rapid increases in middle ear pressure and the generation of a positive middle ear pressure were associated with nose blowing. No evidence was found to support the hypothesis that negative middle ear pressures are associated with sniffing.
对8名有症状的急性上呼吸道感染患者（年龄18 - 32岁）进行了7个半小时的中耳压力和鼻气道阻力测量。平均中耳压力为-13±1.5 daPa（标准误），范围在65至-140 daPa之间。平均总鼻阻力为0.4±0.02 Pa/cm³/s（标准误），范围在0.20至1.28 Pa/cm³/s之间。单侧鼻气道阻力呈现相互波动，范围在0.18 - 3.60 Pa/cm³/s之间。每个受试者最高和最低单侧鼻阻力值之间的平均差异为1.48±0.22 Pa/cm³/s（n = 16）。未发现单侧鼻气道阻力与中耳压力之间存在相关性。总鼻气道阻力与中耳压力呈负相关，r = 0.32，r² = 0.11，n = 176（p < 0.001）。结果表明，急性上呼吸道感染时中耳负压的产生方式与咽鼓管间歇性阻塞和中耳气体逐渐吸收一致。中耳压力的快速升高和中耳正压的产生与擤鼻有关。没有证据支持中耳负压与吸气有关的假设。
