Halliday D, Venkatesan S, Pacy P
Nutrition Research Group, Clinical Research Centre, Harrow, Middlesex, UK.
Am J Clin Nutr. 1993 May;57(5 Suppl):726S-730S; discussion 730S-731S. doi: 10.1093/ajcn/57.5.726S.
Lipids are the major fuel of the body. Efficient functioning as an energy source dictates that lipids must be transportable in the plasma from the point of synthesis and assembly to the storage depots and finally to the tissues to provide energy through oxidative metabolism. Complex lipid forms are transported through the plasma as lipoprotein particles. These particles, secreted from the intestine and liver, have nonpolar outer surface composed of cholesterol, phospholipids, and apolipoproteins. Apolipoproteins are essential for the production, secretion, and continued structural integrity of the various lipoprotein particles and thus play a pivotal role in the control mechanisms of lipid transport. Apolipoproteins regulate specific enzyme activities and modulate plasma lipoprotein clearance through receptor-mediated processes. Quantitative information regarding the rates of synthesis and catabolism of apolipoproteins is vital to an understanding of their metabolism in health and disease. General considerations are followed by a specific use of stable-isotope methodology to quantitative the rate of synthesis of very-low-density-lipoprotein apolipoprotein B-100 (VLDL apo B-100) in control and familial-combined-hyperlipidemic (FCHL) patients.
脂质是身体的主要燃料。作为一种能源高效发挥作用意味着脂质必须在血浆中从合成和组装部位运输到储存库，最终运输到组织，通过氧化代谢提供能量。复杂的脂质形式以脂蛋白颗粒的形式在血浆中运输。这些颗粒由肠道和肝脏分泌，具有由胆固醇、磷脂和载脂蛋白组成的非极性外表面。载脂蛋白对于各种脂蛋白颗粒的产生、分泌和持续的结构完整性至关重要，因此在脂质运输的控制机制中起着关键作用。载脂蛋白调节特定酶的活性，并通过受体介导的过程调节血浆脂蛋白的清除。关于载脂蛋白合成和分解代谢速率的定量信息对于理解其在健康和疾病中的代谢至关重要。在一般考虑之后，将具体介绍使用稳定同位素方法定量对照和家族性混合性高脂血症（FCHL）患者极低密度脂蛋白载脂蛋白B-100（VLDL apo B-100）的合成速率。
