Mani S, Kocheril A G, Andriole V T
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
Am J Med Sci. 1993 Apr;305(4):236-40. doi: 10.1097/00000441-199304000-00007.
Pentamidine isethionate has been associated with ventricular tachyarrhythmias, including torsade de pointes. This article reports two cases of this complication and reviews all reported cases to date. Pentamidine-induced torsade de pointes may be related to serum magnesium levels and hypomagnesemia may synergistically induce torsade. Torsade de pointes occurred after an average of 10 days of treatment with pentamidine. In these patients, no other acute side effects of pentamidine were observed. Torsade de pointes can be treated when recognized early, possibly without discontinuation of pentamidine. When QTc interval prolongation is observed, early magnesium supplementation is advocated.
