Cardiff R D, Leder A, Kuo A, Pattengale P K, Leder P
Department of Pathology, School of Medicine, University of California, Davis 95616.
Am J Pathol. 1993 Apr;142(4):1199-207.
A transgenic mouse strain with the zeta-globin promoter and the vHa-ras oncogene develops an array of mesenchymal and epithelial neoplasms described here. The predominate mesenchymal tumors were dermal spindle cell tumors, which resembled malignant fibrous histiocytomas found in humans. They were associated with hepatosplenomegaly and developed beneath squamous papillomas. The hepatosplenomegaly was associated with infiltrates of cells that tended toward myelocytic or monocytic differentiation. Other epithelial tumors included keratoacanthomas and squamous cell carcinomas. Squamous cysts, some with squamous cell carcinomas, of the salivary glands and mammary carcinomas were also found. Odontogenic tumors, which sometimes differentiated into ameloblastomas, were one of the more unusual tumor types observed. Other, less frequent tumors were also noted. The tumors described here are a potentially valuable experimental resource that may lead to an understanding of malignant fibrous histiocytoma-like lesions, odontogenic tumors, and tumor progression.
一种带有ζ-珠蛋白启动子和vHa-ras癌基因的转基因小鼠品系会发生一系列间充质和上皮性肿瘤，在此予以描述。主要的间充质肿瘤是皮肤梭形细胞瘤，类似于人类的恶性纤维组织细胞瘤。它们与肝脾肿大相关，并在鳞状乳头状瘤下方发生。肝脾肿大与倾向于髓细胞或单核细胞分化的细胞浸润有关。其他上皮性肿瘤包括角化棘皮瘤和鳞状细胞癌。还发现了唾液腺鳞状囊肿，有些伴有鳞状细胞癌，以及乳腺癌。牙源性肿瘤有时会分化成成釉细胞瘤，是观察到的较为不寻常的肿瘤类型之一。还注意到了其他不太常见的肿瘤。这里描述的肿瘤是一种潜在有价值的实验资源，可能有助于理解恶性纤维组织细胞瘤样病变、牙源性肿瘤和肿瘤进展。
