Chaudhuri T K, Fink S, Netto I C, Wilson S K, Kolm P
Nuclear Medicine Service, VA Medical Center, Hampton, Virginia.
Clin Auton Res. 1993 Feb;3(1):37-40. doi: 10.1007/BF01819141.
The effect of the prostaglandin synthetase inhibitor, indomethacin on urodynamic values measured by radionuclide imaging was studied in 17 men in a double-blind placebo controlled randomized trial. Measurements were made of voiding time, time for 50% emptying, average flow rate, ejection fraction, post-void residual urine volume, voided volume, and total bladder volume. Statistical analyses indicated no placebo-indomethacin differences between the two groups. Although prostaglandins are thought to contribute to the act of micturition by maintenance of bladder tone and contractility, our studies indicate that a standard dose of the prostaglandin inhibitor, indomethacin, did not affect the voiding component of bladder function. Patients need not discontinue prostaglandin inhibitors and other non-steroidal anti-inflammatory drugs with such effects prior to urodynamic testing.
在一项双盲、安慰剂对照的随机试验中，对17名男性研究了前列腺素合成酶抑制剂吲哚美辛对放射性核素成像测量的尿动力学值的影响。测量了排尿时间、50%排空时间、平均流速、射血分数、排尿后残余尿量、排尿量和膀胱总体积。统计分析表明两组之间安慰剂与吲哚美辛无差异。虽然前列腺素被认为通过维持膀胱张力和收缩力促进排尿动作，但我们的研究表明，标准剂量的前列腺素抑制剂吲哚美辛并不影响膀胱功能的排尿成分。患者在进行尿动力学检查前无需停用具有此类作用的前列腺素抑制剂和其他非甾体抗炎药。
