Yadin H, Roozelaar D J, Hoekstra J
Tijdschr Diergeneeskd. 1977 Mar 1;102(5):318-25.
Three passages of goose hepatitis virus of muscoy duck embryo cell cultures were used as a vaccine in geese. The offspring of birds inoculated with the thirty-second of fifty-fifth passage were found to be immune to experimental infection with virulent goose hepatitis virus. The fifty-fifth passage, inoculated intramuscularly, did not result in transmission of the virus, neither through the hatching egg nor by direct contact. The eight-seventh passage was non-pathogenic for susceptible day-old goslings and produced active and adequate immunity in these young birds.
番鸭胚细胞培养的鹅肝炎病毒传代3次后用作鹅的疫苗。接种第55代第32代的禽类后代对强毒鹅肝炎病毒的实验感染具有免疫力。第55代经肌肉注射接种后,病毒既未通过孵化蛋传播,也未通过直接接触传播。第87代对易感的1日龄雏鹅无致病性,并在这些幼禽中产生了积极且充分的免疫力。