Kawasaki K, Tsuji T, Hirase K, Miyano M, Inouye S, Iwamoto M
Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Chem Pharm Bull (Tokyo). 1993 Mar;41(3):525-8. doi: 10.1248/cpb.41.525.
Various peptides related to N-terminal portion of fibrin alpha-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal tripeptide decreased the inhibitory effect. The most potent effect was shown by N-terminal decapeptide analog, H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH2.
通过溶液法和固相法合成了与纤维蛋白α链N端部分相关的各种肽，并检测了它们对纤维蛋白原/凝血酶凝血的抑制作用。从N端三肽开始延长肽链会降低抑制作用。N端十肽类似物H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH2显示出最强的作用。
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