Rose M E, Hesketh P, Ogilvie B M
Immunology. 1979 Jan;36(1):71-9.
The peripheral blood leucocyte (PBL) response to infection with two species of the intestinal protozoan Eimeria shows a remarkably similar pattern in both rats and chickens. Like resistance to these parasites, the PBL response to reinfection is species-specific and it coincides with the inhibition of development of the parasite and with cellular infiltration of the lamina propria. In primary infections, the numbers of PBL increased biphasically and significant changes were found in the count of polymorphonuclear cells (PMN), lymphocytes, and large mononuclear cells (LMN). A consistent pattern of two increases in PMN, some lymphopenia, and two increases in LMN was found in rats and chickens. The response to secondary infections was more rapid and much briefer, particularly in chickens in which significant changes were detected within hours of infection and consisted of an almost equal increase in PMN and in lymphocytes. This secondary response occurred only in animals challenged with the homologous species. It was not evoked by challenge with a related species which develops in approximately the same area of the intestine.
外周血白细胞（PBL）对两种肠道原生动物艾美耳球虫感染的反应在大鼠和鸡中显示出非常相似的模式。与对这些寄生虫的抵抗力一样，PBL对再次感染的反应具有物种特异性，并且与寄生虫发育的抑制以及固有层的细胞浸润同时发生。在初次感染中，PBL数量呈双相增加，并且在多形核细胞（PMN）、淋巴细胞和大单核细胞（LMN）计数中发现了显著变化。在大鼠和鸡中发现了PMN两次增加、一些淋巴细胞减少和LMN两次增加的一致模式。对二次感染的反应更快且持续时间更短，特别是在鸡中，在感染后数小时内就检测到显著变化，包括PMN和淋巴细胞几乎同等程度的增加。这种二次反应仅发生在用同源物种攻击的动物中。用在肠道大致相同区域发育的相关物种攻击不会引发这种反应。
