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Oligoclonal expansion of major histocompatibility complex class I-restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction.体内初次免疫应答期间主要组织相容性复合体I类限制性细胞毒性T淋巴细胞的寡克隆扩增：通过流式细胞术和聚合酶链反应进行直接监测
J Exp Med. 1993 May 1;177(5):1487-92. doi: 10.1084/jem.177.5.1487.
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H-2-restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity.对HLA具有特异性的H - 2限制性细胞溶解T淋巴细胞表现出有限多样性的T细胞受体。
J Exp Med. 1992 Aug 1;176(2):439-47. doi: 10.1084/jem.176.2.439.
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T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone.自体黑色素瘤反应性细胞毒性T淋巴细胞（CTL）克隆的T细胞受体（TCR）结构：肿瘤浸润淋巴细胞在体内过度表达一种由HLA - A2限制性且黑色素细胞谱系特异性CTL克隆所使用的TCRβ链序列。
J Exp Med. 1993 Oct 1;178(4):1231-46. doi: 10.1084/jem.178.4.1231.
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Induction of CTL in vivo by major histocompatibility complex class I-peptide complexes covalently associated on the cell surface.通过与细胞表面共价结合的主要组织相容性复合体I类-肽复合物在体内诱导细胞毒性T淋巴细胞。
Eur J Immunol. 1995 Jun;25(6):1535-40. doi: 10.1002/eji.1830250610.
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Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.人类HLA - A0201限制性细胞毒性T淋巴细胞对甲型流感的识别主要由携带Vβ17基因片段的T细胞主导。
J Exp Med. 1995 Jan 1;181(1):79-91. doi: 10.1084/jem.181.1.79.
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Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones.由Ld限制的肿瘤肽特异性细胞毒性T淋巴细胞克隆产生的偏向性T细胞受体使用情况。
J Immunol. 1993 Feb 1;150(3):800-11.
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Synthetic peptides as antigens and competitors in recognition by H-2-restricted cytolytic T cells specific for HLA.合成肽作为被H-2限制的、针对HLA的溶细胞性T细胞识别中的抗原和竞争者。
J Exp Med. 1988 Apr 1;167(4):1391-405. doi: 10.1084/jem.167.4.1391.
引用本文的文献
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Multi-variate model of T cell clonotype competition and homeostasis.T 细胞克隆型竞争和动态平衡的多变量模型。
Sci Rep. 2023 Dec 11;13(1):21995. doi: 10.1038/s41598-023-46637-4.
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Antigen-specific and cross-reactive T cells in protection and disease.抗原特异性和交叉反应性 T 细胞在保护和疾病中的作用。
Immunol Rev. 2023 Jul;316(1):120-135. doi: 10.1111/imr.13217. Epub 2023 May 20.
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Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor.多个针对同一外来肽 - 主要组织相容性复合体（pMHC）配体的T细胞克隆可从单个祖先T细胞受体β链可变区、多样性区和连接区（TCR-VDJβ）前体产生。
Immunol Res. 2004;30(2):231-40. doi: 10.1385/IR:30:2:231.
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In vivo administration of a lentiviral vaccine targets DCs and induces efficient CD8(+) T cell responses.慢病毒疫苗的体内给药靶向树突状细胞并诱导有效的CD8(+) T细胞反应。
J Clin Invest. 2003 Jun;111(11):1673-81. doi: 10.1172/JCI17098.
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T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires.T细胞受体基因重排谱系分析揭示了高度受限的抗原特异性库起源的线索。
J Exp Med. 2003 Mar 3;197(5):601-14. doi: 10.1084/jem.20021945.
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Individuality of Ag-selected and preimmune TCR repertoires.抗原选择的和免疫前T细胞受体库的个体性。
Immunol Res. 2001;23(1):75-84. doi: 10.1385/IR:23:1:75.
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T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo.体内CD4(+) T细胞反应启动过程中T细胞受体（TCR）介导的 repertoire 选择及TCR vβ多样性的丧失
J Exp Med. 2000 Dec 18;192(12):1719-30. doi: 10.1084/jem.192.12.1719.
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Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo.体内CD8(+) T细胞对莫洛尼白血病病毒编码的免疫显性表位应答中不同T细胞受体Vβ基因片段的分层利用
J Virol. 1999 Nov;73(11):9161-9. doi: 10.1128/JVI.73.11.9161-9169.1999.
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T cell receptor usage in infectious disease.传染病中T细胞受体的使用情况。
Springer Semin Immunopathol. 1999;21(1):37-54. doi: 10.1007/BF00815177.
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The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones.初始T细胞反应的组成很大程度上由各个T细胞克隆募集的时间决定。
J Exp Med. 1999 May 17;189(10):1591-600. doi: 10.1084/jem.189.10.1591.
本文引用的文献
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Clonal expansion of T cells: a cytotoxic T-cell response in vivo that involves precursor cell proliferation.T细胞的克隆性扩增：一种体内细胞毒性T细胞反应，涉及前体细胞增殖。
Proc Natl Acad Sci U S A. 1986 Aug;83(16):6089-92. doi: 10.1073/pnas.83.16.6089.
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H2-restricted recognition of cloned HLA class I gene products expressed in mouse cells.对在小鼠细胞中表达的克隆化HLA I类基因产物的H2限制性识别。
J Immunol. 1986 Jun 15;136(12):4340-7.
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Two monoclonal antibodies specific for the T cell receptor V alpha 8.两种针对T细胞受体Vα8的单克隆抗体。
Eur J Immunol. 1989 Jun;19(6):1131-5. doi: 10.1002/eji.1830190625.
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Optimal conditions for directly sequencing double-stranded PCR products with sequenase.使用测序酶对双链PCR产物进行直接测序的最佳条件。
Nucleic Acids Res. 1990 Jul 11;18(13):4028. doi: 10.1093/nar/18.13.4028.
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Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity.成熟T细胞的胸腺外耐受：作为免疫结果的克隆清除。
Cell. 1990 Dec 21;63(6):1249-56. doi: 10.1016/0092-8674(90)90420-j.
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Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo.在体内对葡萄球菌肠毒素B作出反应的Vβ8 +外周T细胞出现无反应性和死亡之前，会发生克隆性扩增。
Eur J Immunol. 1991 Aug;21(8):1963-6. doi: 10.1002/eji.1830210827.
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T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.一系列针对伯氏疟原虫九肽的I类主要组织相容性复合体限制性细胞毒性T淋巴细胞克隆中的T细胞受体基因：对T细胞等位基因排斥和抗原特异性库的影响
J Exp Med. 1991 Dec 1;174(6):1371-83. doi: 10.1084/jem.174.6.1371.
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A special repertoire of alpha:beta T cells in neonatal mice.新生小鼠中α:β T细胞的特殊库。
EMBO J. 1991 Dec;10(12):3647-54. doi: 10.1002/j.1460-2075.1991.tb04931.x.
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H-2Kd-restricted antigenic peptides share a simple binding motif.H-2Kd限制的抗原肽具有一个简单的结合基序。
J Exp Med. 1991 Sep 1;174(3):603-12. doi: 10.1084/jem.174.3.603.
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