Delbeke D, Lorenz C H, Votaw J R, Silveira S T, Frist W H, Atkinson J B, Kessler R M, Sandler M P
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232.
J Nucl Med. 1993 May;34(5):826-33.
The purpose of this study was to develop a technique to quantify left ventricular mass and infarct size in chronic ischemic heart disease from PET images based on correlation with pathological examination of explanted human hearts. Fourteen hearts from patients with cardiomyopathy who had 13N-ammonia scans prior to orthoptic heart transplantation were studied. Accurate estimation of the relative infarct size was possible in patients with a well-delineated, nearly transmural infarct (r = 0.93, y = 1.1x - 0.7, n = 11). Both absolute and relative infarct mass measurements on PET images correlated well with pathological measurements. We identified a population of patients with patchy interstitial or subendocardial scarring with globally reduced perfusion, for which the infarct size could not be estimated using the criteria derived for the patients with well-delineated infarcts.
本研究的目的是开发一种技术，基于与移植人心脏病理检查的相关性，从PET图像中量化慢性缺血性心脏病患者的左心室质量和梗死面积。对14例在直视心脏移植前进行过13N-氨扫描的心肌病患者的心脏进行了研究。对于梗死灶边界清晰、几乎透壁的患者，能够准确估计相对梗死面积（r = 0.93，y = 1.1x - 0.7，n = 11）。PET图像上梗死灶的绝对质量和相对质量测量值与病理测量值均具有良好的相关性。我们发现了一群存在斑片状间质或心内膜下瘢痕且整体灌注降低的患者，对于这类患者，无法使用针对梗死灶边界清晰患者得出的标准来估计梗死面积。
