Inoue Y, Machida K, Honda N, Mamiya T, Takahashi T, Kamano T, Kashimada A
Department of Radiology, Saitama Medical Center, Saitama Medical School.
Kaku Igaku. 1993 Mar;30(3):313-6.
We studied clearance of a new myocardial perfusion imaging agent, 99mTc-Tetrofosmin, from the myocardium and the adjacent organs in nine patients. 99mTc-Tetrofosmin was injected intravenously at stress and at rest, and SPECT images were obtained 25 min and 120 min later. Anterior view images were also obtained 10 min and 150 min after the injection to compare the myocardial clearance with those from the liver and lung. Clearance from the liver was faster than those from the myocardium and lung. Washout rate calculated with SPECT was higher for the inferior wall than for the anterior wall and lateral wall (p < 0.05 at rest, N.S. at stress). The value was higher at stress in any region than at rest (the anterior wall and lateral wall, p < 0.01; the septum, p < 0.05; the inferior wall, N.S.). Washout rate for the anterior wall was 3.4 +/- 14.0% at rest and 18.0 +/- 10.6% at stress. The rate for the lateral wall was 2.7 +/- 22.5% at rest and 15.8 +/- 7.9% at stress. It was suggested that rapid hepatic clearance and high myocardial washout at stress may be important in determining the period between the injection of 99mTc-Tetrofosmin and the data acquisition for SPECT imaging.
我们研究了一种新型心肌灌注显像剂99mTc-替曲膦在9例患者心肌及邻近器官中的清除情况。在负荷和静息状态下经静脉注射99mTc-替曲膦，分别于注射后25分钟和120分钟采集单光子发射计算机断层扫描（SPECT）图像。注射后10分钟和150分钟还采集了前位图像，以比较心肌清除情况与肝脏和肺的清除情况。肝脏的清除速度比心肌和肺更快。SPECT计算的下壁洗脱率高于前壁和侧壁（静息时p<0.05，负荷时无显著性差异）。任何区域负荷时的值均高于静息时（前壁和侧壁，p<0.01；间隔，p<0.05；下壁，无显著性差异）。前壁静息时洗脱率为3.4±14.0%，负荷时为18.0±10.6%。侧壁静息时洗脱率为2.7±22.5%，负荷时为15.8±7.9%。提示肝脏快速清除和负荷时心肌高洗脱率在确定99mTc-替曲膦注射与SPECT成像数据采集之间的时间间隔方面可能很重要。
