Tucker S M, Hurwitz J J, Pavlin C J, Howarth D J, Nianiaris N
Department of Ophthalmology, University of Toronto, Ontario, Canada.
Ophthalmology. 1993 Apr;100(4):574-7. doi: 10.1016/s0161-6420(13)31630-3.
The authors report a patient with a cryotherapy-induced scleral melt after combined excision and cryotherapy of a conjunctival melanoma arising within primary acquired melanosis with atypia.
In a 65-year-old white man, a severe scleral melt developed within 1 month of complete excision of a superficial conjunctival melanoma combined with double-freeze-thaw nitrous oxide cryotherapy to the scleral bed and surrounding conjunctival margins. Ultrasound biomicroscopy showed the degree of scleral thinning.
Although many complications associated with cryotherapy have been described in the literature, there are no reports of a scleral melt. Scleral melt is a potential complication of cryotherapy that can occur despite taking precautions and should be monitored in the first few weeks after cryotherapy to the scleral bed of excised conjunctival tumors.
作者报告了1例在对原发性获得性黑素沉着伴异型性的结膜黑色素瘤进行联合切除及冷冻治疗后发生冷冻疗法诱导的巩膜溶解的患者。
在1名65岁白人男性中，在浅表结膜黑色素瘤完全切除并对巩膜床和周围结膜边缘进行双冻融一氧化二氮冷冻治疗后的1个月内发生了严重的巩膜溶解。超声生物显微镜检查显示了巩膜变薄的程度。
尽管文献中描述了许多与冷冻疗法相关的并发症，但尚无巩膜溶解的报道。巩膜溶解是冷冻疗法的一种潜在并发症，尽管采取了预防措施仍可能发生，应对切除的结膜肿瘤巩膜床进行冷冻治疗后的最初几周进行监测。
