Oka Y, Himeno E, Nakashima Y, Kuroiwa A, Hachiya Y, Ohe K
Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1993 Mar 1;15(1):29-35. doi: 10.7888/juoeh.15.29.
Since higher levels of serum triglycerides were frequently found during the UOEH physical check-up for employees and students in 1989, we analysed subjects with higher triglyceride levels and discussed ways of handling them. Blood sampling to determine serum lipids was done between 13:00-15:00. Of the total (males 1257, females 1267), 272 had higher serum triglyceride levels (over 200 mg/dl) (males 246, females 26) (1st TG). One hundred and twenty-one of the group with higher TG levels in the 1st examination were reevaluated by blood sampling the morning after overnight fasting (2nd TG). There was a significant positive correlationship between the TG levels from the 1st examination and those from the 2nd examination (r = 0.62, n = 121, P < 0.0001). The predictive value calculated from the equation between the TG in the first and second measurements was 341.7 mg/dl. There was a 14.9% rate of false negatives in subjects under 341.7 mg/dl on the first TG measurement. However, there were only 6.3% false negatives in the subjects under 250 mg/dl on the first TG measurement. Age, body mass index and serum cholesterol level were significantly higher in the group with the higher TG level on reevaluation (more than 160 mg/dl) than those in the group with the lower TG level on reevaluation (less than 160 mg/dl). We concluded from these results that the casual serum TG levels above 250 mg/dl might be a suitable cut off level in physical check-ups.
由于1989年在东京都立环境卫生研究所对员工和学生进行的体检中经常发现较高水平的血清甘油三酯，我们对甘油三酯水平较高的受试者进行了分析，并讨论了处理方法。在13:00至15:00之间采集血液样本以测定血脂。在总共2524名受试者（男性1257名，女性1267名）中，有272人血清甘油三酯水平较高（超过200mg/dl）（男性246人，女性26人）（首次甘油三酯检测）。对首次检测中甘油三酯水平较高组的121人在过夜禁食后的次日早晨再次进行血液采样重新评估（第二次甘油三酯检测）。首次检测的甘油三酯水平与第二次检测的甘油三酯水平之间存在显著正相关（r = 0.62，n = 121，P < 0.0001）。根据第一次和第二次测量的甘油三酯之间的方程计算出的预测值为341.7mg/dl。在首次甘油三酯测量中，低于341.7mg/dl的受试者假阴性率为14.9%。然而，在首次甘油三酯测量中，低于250mg/dl的受试者假阴性率仅为6.3%。重新评估时甘油三酯水平较高组（超过160mg/dl）的年龄、体重指数和血清胆固醇水平显著高于重新评估时甘油三酯水平较低组（低于160mg/dl）。我们从这些结果得出结论，在体检中，随机血清甘油三酯水平高于250mg/dl可能是一个合适的临界值。
