Brudvik C, Hamre E
Bergen Legevakt.
Tidsskr Nor Laegeforen. 1993 Mar 10;113(7):847.
A patient is described who developed fatty tissue necrosis and oil granuloma in her thigh after repeated subcutaneous injection of vitamin B12. The injections were taken in a badly documented attempt to prevent migraine. The preparation used was vitamin B12 combined with a mineral oil to give slow release resorption. We describe the histopathological mechanism for reaction of fatty tissue to mineral oil injections. The 40 ml cavity of fat necrosis had to be drained out several times and over a long period of time before our patient was without symptoms.
本文描述了一名患者，在反复皮下注射维生素B12后，其大腿出现了脂肪组织坏死和油肉芽肿。这些注射是在记录不佳的情况下进行的，目的是预防偏头痛。所使用的制剂是维生素B12与矿物油混合，以实现缓慢释放吸收。我们描述了脂肪组织对矿物油注射反应的组织病理学机制。在患者无症状之前，40毫升的脂肪坏死腔必须多次且长时间引流。
