Ramada Benlloch F J, Gonzalvo Pérez V, Blasco Alfonso E, Donderis Guastavino C, Navalón Verdejo P, Zaragozá Orts J
Servicio de Urología, Hospital General Universitario de Valencia.
Actas Urol Esp. 1993 Feb;17(2):139-42.
Cyclophosphamide has been used since 1958 in the treatment of various malignant tumours and certain systemic diseases, toxicity to the urothelium, frequently causing haemorrhagic cystitis and less often urothelial carcinomas, being one of its most notorious side effects--some 60 urothelial carcinoma cases have been published following therapy with cyclophosphamide since 1971. The present paper is a contribution of two new cases and its raises the need of paying special attention to urinary manifestations as well as narrowing the cooperation between the physicians which prescribe cyclophosphamide and the urologist, in order to make an appropriate follow-up and management of the patient.
