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猪模型中的腹腔镜腹股沟疝修补术。在金牌论文竞赛中获得康拉德·约斯特奖的第三名。

Laparoscopic inguinal herniorrhaphy in a swine model. Third place winner of the Conrad Jobst Award in the Gold Medal paper competition.

作者信息

Layman T S, Burns R P, Chandler K E, Russell W L, Cook R G

机构信息

Department of Surgery, University of Tennessee College of Medicine, Erlanger Medical Center, Chattanooga 37403.

出版信息

Am Surg. 1993 Jan;59(1):13-9.

PMID:8480925
Abstract

A simplified method of laparoscopic inguinal herniorrhaphy using prosthetic materials was evaluated in a swine hernia model. The goals of this study were to determine 1) effectiveness of repair in a rapidly growing animal, 2) effectiveness and extent of adhesion formation of different prosthetic materials, 3) the effect of repair on testicular growth, and 4) histologic effects on the hernia site and surrounding structures. In a prospective randomized study, 30 juvenile male swine (average, 23 kg) with 35 congenital indirect inguinal hernias underwent laparoscopic herniorrhaphy using one of three prosthetic materials: Group 1 (polytetrafluoroethylene/Gore-Tex), N = 10; Group 2 (polypropylene mesh/Marlex), N = 10; Group 3 (polypropylene mesh/Prolene), N = 10. A standardized laparoscopic herniorrhaphy technique consisting of stapling prosthetic material over the hernia defect without peritoneal dissection was employed. During the 3-month postoperative period, animals were sequentially examined for normal growth and development, normal testicular development, and signs of hernia recurrence. Clinically apparent complications related to herniorrhaphy occurred in five animals (17%) during the observation period (one with repair failure, one with testicular torsion, two with repair failure and bowel obstruction, and one with intestinal obstruction secondary to adhesions). All three animals with bowel obstruction died. At 90 days after surgery all remaining animals (N = 27) were euthanized (Group 1 = 9, Group 2 = 8, Group 3 = 10). Average weight was 84 kg. Necropsy findings included no additional hernia recurrences, and one mesh erosion into the urinary bladder.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在猪疝模型中评估了一种使用假体材料的简化腹腔镜腹股沟疝修补方法。本研究的目的是确定:1)在快速生长动物中修复的有效性;2)不同假体材料粘连形成的有效性和程度;3)修复对睾丸生长的影响;4)对疝部位和周围结构的组织学影响。在一项前瞻性随机研究中,30只患有35处先天性间接腹股沟疝的幼年雄性猪(平均体重23千克)接受了腹腔镜疝修补术,使用三种假体材料之一:第1组(聚四氟乙烯/戈尔特斯),N = 10;第2组(聚丙烯网片/马利克斯),N = 10;第3组(聚丙烯网片/普理灵),N = 10。采用了一种标准化的腹腔镜疝修补技术,即在不进行腹膜剥离的情况下将假体材料缝合在疝缺损上。在术后3个月期间,对动物依次进行检查,以观察其正常生长发育、正常睾丸发育以及疝复发迹象。在观察期内,有5只动物(17%)出现了与疝修补术相关的明显临床并发症(1例修补失败,1例睾丸扭转,2例修补失败并伴有肠梗阻,1例因粘连继发肠梗阻)。所有3例肠梗阻动物均死亡。术后90天,所有剩余动物(N = 27)均被安乐死(第1组 = 9只,第2组 = 8只,第3组 = 10只)。平均体重为84千克。尸检结果包括无额外的疝复发,以及1例网片侵蚀膀胱。(摘要截短至250字)

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